Cell-cycle-dependent transcriptional and translational DNA-damage response of 2 ribonucleotide reductase genes in S. cerevisiae

The ribonucleotide reductase (RNR) enzyme catalyzes an essential step in the production of deoxyribonucleotide triphosphates (dNTPs) in cells. Bulk biochemical measurements in synchronized Saccharomyces cerevisiae cells suggest that RNR mRNA production is maximal in late G1 and S phases; however, da...

Full description

Bibliographic Details
Main Authors: Mazumder, Aprotim, Tummler, Katja, Bathe, Mark, Samson, Leona D
Other Authors: Massachusetts Institute of Technology. Center for Environmental Health Sciences
Format: Article
Language:en_US
Published: American Society for Microbiology 2013
Online Access:http://hdl.handle.net/1721.1/76311
https://orcid.org/0000-0002-6199-6855
https://orcid.org/0000-0002-7112-1454