Three-Dimensional Genome Architecture Influences Partner Selection for Chromosomal Translocations in Human Disease

Three-Dimensional Genome Architecture Influences Partner Selection for Chromosomal Translocations in Human Disease

Chromosomal translocations are frequent features of cancer genomes that contribute to disease progression. These rearrangements result from formation and illegitimate repair of DNA double-strand breaks (DSBs), a process that requires spatial colocalization of chromosomal breakpoints. The “contact fi...

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Bibliographic Details
Main Authors: Engreitz, Jesse Michael, Agarwala, Vineeta, Mirny, Leonid A.
Other Authors: Harvard University--MIT Division of Health Sciences and Technology
Format: Article
Language:en_US
Published: Public Library of Science 2013
Online Access:http://hdl.handle.net/1721.1/76617
https://orcid.org/0000-0002-5754-1719
https://orcid.org/0000-0002-0785-5410

Internet

http://hdl.handle.net/1721.1/76617
https://orcid.org/0000-0002-5754-1719
https://orcid.org/0000-0002-0785-5410

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