Three-Dimensional Genome Architecture Influences Partner Selection for Chromosomal Translocations in Human Disease

Chromosomal translocations are frequent features of cancer genomes that contribute to disease progression. These rearrangements result from formation and illegitimate repair of DNA double-strand breaks (DSBs), a process that requires spatial colocalization of chromosomal breakpoints. The “contact fi...

ver descrição completa

Detalhes bibliográficos
Principais autores: Engreitz, Jesse Michael, Agarwala, Vineeta, Mirny, Leonid A.
Outros Autores: Harvard University--MIT Division of Health Sciences and Technology
Formato: Artigo
Idioma:en_US
Publicado em: Public Library of Science 2013
Acesso em linha:http://hdl.handle.net/1721.1/76617
https://orcid.org/0000-0002-5754-1719
https://orcid.org/0000-0002-0785-5410