Three-Dimensional Genome Architecture Influences Partner Selection for Chromosomal Translocations in Human Disease
Chromosomal translocations are frequent features of cancer genomes that contribute to disease progression. These rearrangements result from formation and illegitimate repair of DNA double-strand breaks (DSBs), a process that requires spatial colocalization of chromosomal breakpoints. The “contact fi...
| Principais autores: | , , |
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| Formato: | Artigo |
| Idioma: | en_US |
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Public Library of Science
2013
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| Acesso em linha: | http://hdl.handle.net/1721.1/76617 https://orcid.org/0000-0002-5754-1719 https://orcid.org/0000-0002-0785-5410 |