Programmable Sequence-Specific Transcriptional Regulation of Mammalian Genome Using Designer TAL Effectors

Programmable Sequence-Specific Transcriptional Regulation of Mammalian Genome Using Designer TAL Effectors

The ability to direct functional proteins to specific DNA sequences is a long-sought goal in the study and engineering of biological processes. Transcription activator–like effectors (TALEs) from Xanthomonas sp. are site-specific DNA-binding proteins that can be readily designed to target new sequen...

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Bibliographic Details
Main Authors: Zhang, Feng, Cong, Le, Lodato, Simona, Kosuri, Sriram, Church, George M., Arlotta, Paola
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Format: Article
Language:en_US
Published: Nature Publishing Group 2013
Online Access:http://hdl.handle.net/1721.1/76706
https://orcid.org/0000-0003-2782-2509

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http://hdl.handle.net/1721.1/76706
https://orcid.org/0000-0003-2782-2509

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