Phenanthriplatin, a monofunctional DNA-binding platinum anticancer drug candidate with unusual potency and cellular activity profile
Monofunctional platinum(II) complexes of general formula cis-[Pt(NH3)2(N-heterocycle)Cl]Cl bind DNA at a single site, inducing little distortion in the double helix. Despite this behavior, these compounds display significant antitumor properties, with a different spectrum of activity than that of cl...
| Prif Awduron: | , , , |
|---|---|
| Awduron Eraill: | |
| Fformat: | Erthygl |
| Iaith: | en_US |
| Cyhoeddwyd: |
National Academy of Sciences (U.S.)
2013
|
| Mynediad Ar-lein: | http://hdl.handle.net/1721.1/76786 https://orcid.org/0000-0002-2693-4982 |