Inference of RhoGAP/GTPase regulation using single-cell morphological data from a combinatorial RNAi screen

Biological networks are highly complex systems, consisting largely of enzymes that act as molecular switches to activate/inhibit downstream targets via post-translational modification. Computational techniques have been developed to perform signaling network inference using some high-throughput data...

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Bibliographic Details
Main Authors: Nir, Oaz, Bakal, Chris, Perrimon, Norbert, Berger, Bonnie
Other Authors: Harvard University--MIT Division of Health Sciences and Technology
Format: Article
Language:en_US
Published: Cold Spring Harbor Laboratory Press 2013
Online Access:http://hdl.handle.net/1721.1/76795
https://orcid.org/0000-0002-2724-7228