Conserved features of intermediates in amyloid assembly determine their benign or toxic states

Conserved features of intermediates in amyloid assembly determine their benign or toxic states

Some amyloid-forming polypeptides are associated with devastating human diseases and others provide important biological functions. For both, oligomeric intermediates appear during amyloid assembly. Currently we have few tools for characterizing these conformationally labile intermediates and discer...

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Bibliographic Details
Main Authors: Krishnan, Rajaraman, Goodman, Jessica L., Mukhopadhyay, Samrat, Pacheco, Chris D., Lemke, Edward A., Deniz, Ashok A., Lindquist, Susan
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: National Academy of Sciences 2013
Online Access:http://hdl.handle.net/1721.1/77145
https://orcid.org/0000-0003-1307-882X

Internet

http://hdl.handle.net/1721.1/77145
https://orcid.org/0000-0003-1307-882X

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