Non Linear Programming (NLP) Formulation for Quantitative Modeling of Protein Signal Transduction Pathways

Modeling of signal transduction pathways plays a major role in understanding cells' function and predicting cellular response. Mathematical formalisms based on a logic formalism are relatively simple but can describe how signals propagate from one protein to the next and have led to the constru...

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Bibliographic Details
Main Authors: Mitsos, Alexander, Melas, Ioannis N., Morris, Melody Kay, Saez-Rodriguez, Julio, Lauffenburger, Douglas A., Alexopoulos, Leonidas G.
Other Authors: Massachusetts Institute of Technology. Cell Decision Process Center
Format: Article
Language:en_US
Published: Public Library of Science 2013
Online Access:http://hdl.handle.net/1721.1/77202