Sequence-dependent sliding kinetics of p53
Proper timing of gene expression requires that transcription factors (TFs) efficiently locate and bind their target sites within a genome. Theoretical studies have long proposed that one-dimensional sliding along DNA while simultaneously reading its sequence can accelerate TF’s location of target si...
Main Authors: | Leith, Jason S., Tafvizi, Anahita, Huang, Fang, Uspal, William Eric, Fersht, Alan R., Oijen, Antoine M. van, Doyle, Patrick S, Mirny, Leonid A |
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Other Authors: | Massachusetts Institute of Technology. Institute for Medical Engineering & Science |
Format: | Article |
Language: | en_US |
Published: |
National Academy of Sciences (U.S.)
2013
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Online Access: | http://hdl.handle.net/1721.1/77237 https://orcid.org/0000-0002-0785-5410 |
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