Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function

Entry of tumor cells into the blood stream is a critical step in cancer metastasis. Although significant progress has been made in visualizing tumor cell motility in vivo, the underlying mechanism of cancer cell intravasation remains largely unknown. We developed a microfluidic-based assay to recrea...

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Bibliographic Details
Main Authors: Zervantonakisa, Ioannis K., Hughes-Alford, Shannon Kay, Charest, Joseph L., Condeelis, John S., Gertler, Frank, Kamm, Roger Dale
Other Authors: Charles Stark Draper Laboratory
Format: Article
Language:en_US
Published: National Academy of Sciences (U.S.) 2013
Online Access:http://hdl.handle.net/1721.1/77583
https://orcid.org/0000-0003-3214-4554
https://orcid.org/0000-0002-7232-304X