Augmented cholesterol absorption and sarcolemmal sterol enrichment slow small intestinal transit in mice, contributing to cholesterol cholelithogenesis

Cholesterol gallstones are associated with slow intestinal transit in humans as well as in animal models, but the molecular mechanism is unknown. We investigated in C57L/J mice whether the components of a lithogenic diet (LD; 1.0% cholesterol, 0.5% cholic acid and 17% triglycerides), as well as dist...

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Bibliographic Details
Main Authors: Fox, James G., Xie, Meimin, Kotecha, Vijay R., Andrade, Jon David P., Carey, Martin C.
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Wiley Blackwell (Blackwell Publishing -The Physiological Society) 2013
Online Access:http://hdl.handle.net/1721.1/78010
https://orcid.org/0000-0001-9307-6116