SOX2 Co-Occupies Distal Enhancer Elements with Distinct POU Factors in ESCs and NPCs to Specify Cell State

SOX2 Co-Occupies Distal Enhancer Elements with Distinct POU Factors in ESCs and NPCs to Specify Cell State

SOX2 is a master regulator of both pluripotent embryonic stem cells (ESCs) and multipotent neural progenitor cells (NPCs); however, we currently lack a detailed understanding of how SOX2 controls these distinct stem cell populations. Here we show by genome-wide analysis that, while SOX2 bound to a d...

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Bibliographic Details
Main Authors: Lodato, Michael Anthony, Ng, Christopher W., Wamstad, Joseph Alan, Cheng, Albert W., Thai, Kevin Kinh, Fraenkel, Ernest, Jaenisch, Rudolf, Boyer, Laurie
Other Authors: Massachusetts Institute of Technology. Computational and Systems Biology Program
Format: Article
Language:en_US
Published: Public Library of Science 2013
Online Access:http://hdl.handle.net/1721.1/78345
https://orcid.org/0000-0002-5239-9557
https://orcid.org/0000-0002-2902-7288
https://orcid.org/0000-0003-1381-4313
https://orcid.org/0000-0001-9249-8181
https://orcid.org/0000-0003-3491-4962

Internet

http://hdl.handle.net/1721.1/78345
https://orcid.org/0000-0002-5239-9557
https://orcid.org/0000-0002-2902-7288
https://orcid.org/0000-0003-1381-4313
https://orcid.org/0000-0001-9249-8181
https://orcid.org/0000-0003-3491-4962

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