Fragile X mental retardation protein and synaptic plasticity

Fragile X mental retardation protein and synaptic plasticity

Loss of the translational repressor FMRP causes Fragile X syndrome. In healthy neurons, FMRP modulates the local translation of numerous synaptic proteins. Synthesis of these proteins is required for the maintenance and regulation of long-lasting changes in synaptic strength. In this role as a trans...

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Bibliographic Details
Main Authors: Sidorov, Michael Samuel, Auerbach, Benjamin David, Bear, Mark
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Format: Article
Language:English
Published: BioMed Central Ltd 2013
Online Access:http://hdl.handle.net/1721.1/78638

Internet

http://hdl.handle.net/1721.1/78638

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