Charge Optimization Theory for Induced-Fit Ligands
The design of ligands with high affinity and specificity remains a fundamental challenge in understanding molecular recognition and developing therapeutic interventions. Charge optimization theory addresses this problem by determining ligand charge distributions that produce the most favorable elect...
| Main Authors: | , , |
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| 其他作者: | |
| 格式: | 文件 |
| 语言: | en_US |
| 出版: |
American Chemical Society (ACS)
2013
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| 在线阅读: | http://hdl.handle.net/1721.1/79088 https://orcid.org/0000-0002-3320-3969 https://orcid.org/0000-0002-1703-7796 |