Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system

Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system

The ability to artificially control transcription is essential both to the study of gene function and to the construction of synthetic gene networks with desired properties. Cas9 is an RNA-guided double-stranded DNA nuclease that participates in the CRISPR-Cas immune defense against prokaryotic viru...

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Bibliographic Details
Main Authors: Zhang, Feng, Bikard, David, Jiang, Wenyan, Samai, Poulami, Hochschild, Ann, Marraffini, Luciano A.
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Oxford University Press 2013
Online Access:http://hdl.handle.net/1721.1/79745
https://orcid.org/0000-0003-2782-2509

Internet

http://hdl.handle.net/1721.1/79745
https://orcid.org/0000-0003-2782-2509

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