Defining principles of combination drug mechanisms of action

Combination chemotherapies have been a mainstay in the treatment of disseminated malignancies for almost 60 y, yet even successful regimens fail to cure many patients. Although their single-drug components are well studied, the mechanisms by which drugs work together in clinical combination regimens...

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Bibliographic Details
Main Authors: Bruno, Peter Michael, Gilbert, Luke Andrew, Capron, Kelsey L., Hemann, Michael, Pritchard, Justin R., Lauffenburger, Douglas A
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: National Academy of Sciences (U.S.) 2013
Online Access:http://hdl.handle.net/1721.1/79755
https://orcid.org/0000-0003-3383-0118