Defining principles of combination drug mechanisms of action
Combination chemotherapies have been a mainstay in the treatment of disseminated malignancies for almost 60 y, yet even successful regimens fail to cure many patients. Although their single-drug components are well studied, the mechanisms by which drugs work together in clinical combination regimens...
Main Authors: | Bruno, Peter Michael, Gilbert, Luke Andrew, Capron, Kelsey L., Hemann, Michael, Pritchard, Justin R., Lauffenburger, Douglas A |
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Other Authors: | Massachusetts Institute of Technology. Department of Biological Engineering |
Format: | Article |
Language: | en_US |
Published: |
National Academy of Sciences (U.S.)
2013
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Online Access: | http://hdl.handle.net/1721.1/79755 https://orcid.org/0000-0003-3383-0118 |
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