Extensive changes in DNA methylation are associated with expression of mutant huntingtin

Extensive changes in DNA methylation are associated with expression of mutant huntingtin

The earliest stages of Huntington disease are marked by changes in gene expression that are caused in an indirect and poorly understood manner by polyglutamine expansions in the huntingtin (HTT) protein. To explore the hypothesis that DNA methylation may be altered in cells expressing mutated HTT, w...

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Bibliographic Details
Main Authors: Ng, Christopher W., Yildirim, Ferah, Yap, Soon Ming Micha, Matthews, Bryan, Velez, Patricio J., Labadorf, Adam, Fraenkel, Ernest, Dalin, Simona, Housman, David E
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: National Academy of Sciences (U.S.) 2013
Online Access:http://hdl.handle.net/1721.1/79762
https://orcid.org/0000-0003-1381-4313
https://orcid.org/0000-0001-5024-9718
https://orcid.org/0000-0001-9249-8181
https://orcid.org/0000-0001-5016-0756

Internet

http://hdl.handle.net/1721.1/79762
https://orcid.org/0000-0003-1381-4313
https://orcid.org/0000-0001-5024-9718
https://orcid.org/0000-0001-9249-8181
https://orcid.org/0000-0001-5016-0756

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