In vitro and in vivo mRNA delivery using lipid-enveloped pHresponsive polymer nanoparticles

In vitro and in vivo mRNA delivery using lipid-enveloped pHresponsive polymer nanoparticles

Biodegradable core−shell structured nanoparticles with a poly(β-amino ester) (PBAE) core enveloped by a phospholipid bilayer shell were developed for in vivo mRNA delivery with a view toward delivery of mRNA-based vaccines. The pH-responsive PBAE component was chosen to promote endosome disruption,...

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Bibliographic Details
Main Authors: Su, Xingfang, Fricke, Jennifer, Kavanagh, Daniel G., Irvine, Darrell J
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: American Chemical Society 2013
Online Access:http://hdl.handle.net/1721.1/79764

Internet

http://hdl.handle.net/1721.1/79764

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