In vitro and in vivo mRNA delivery using lipid-enveloped pHresponsive polymer nanoparticles
Biodegradable core−shell structured nanoparticles with a poly(β-amino ester) (PBAE) core enveloped by a phospholipid bilayer shell were developed for in vivo mRNA delivery with a view toward delivery of mRNA-based vaccines. The pH-responsive PBAE component was chosen to promote endosome disruption,...
Main Authors: | Su, Xingfang, Fricke, Jennifer, Kavanagh, Daniel G., Irvine, Darrell J |
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Other Authors: | Massachusetts Institute of Technology. Department of Biological Engineering |
Format: | Article |
Language: | en_US |
Published: |
American Chemical Society
2013
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Online Access: | http://hdl.handle.net/1721.1/79764 |
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