Exogenous delivery of chaperonin subunit fragment ApiCCT1 modulates mutant Huntingtin cellular phenotypes

Exogenous delivery of chaperonin subunit fragment ApiCCT1 modulates mutant Huntingtin cellular phenotypes

Aggregation of misfolded proteins is characteristic of a number of neurodegenerative diseases, including Huntington disease (HD). The CCT/TRiC (chaperonin containing TCP-1/TCP-1 ring) chaperonin complex can inhibit aggregation and cellular toxicity induced by expanded repeat Huntingtin (mHtt) fragme...

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Bibliographic Details
Main Authors: Sontag, Emily M., Joachimiak, Lukasz A., Tan, Zhiqun, Tomlinson, Anthony, Glabe, Charles G., Potkin, Steven G., Frydman, Judith, Thompson, Leslie M., Housman, David E
Other Authors: Harvard University--MIT Division of Health Sciences and Technology
Format: Article
Language:en_US
Published: National Academy of Sciences (U.S.) 2013
Online Access:http://hdl.handle.net/1721.1/79802
https://orcid.org/0000-0001-5016-0756

Internet

http://hdl.handle.net/1721.1/79802
https://orcid.org/0000-0001-5016-0756

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