Genetic Analysis of Synaptotagmin C2 Domain Specificity in Regulating Spontaneous and Evoked Neurotransmitter Release

Synaptic vesicle fusion mediates communication between neurons and is triggered by rapid influx of Ca[superscript 2+]. The Ca[superscript 2+]-triggering step for fusion is regulated by the synaptic vesicle transmembrane protein Synaptotagmin 1 (Syt1). Syt1 contains two cytoplasmic C2 domains, termed...

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Bibliographic Details
Main Authors: Lee, Jihye, Guan, Zhuo, Akbergenova, Yulia, Littleton, J. Troy
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Society for Neuroscience 2013
Online Access:http://hdl.handle.net/1721.1/79804
https://orcid.org/0000-0001-5576-2887