Impact of deleterious passenger mutations on cancer progression

Cancer progression is driven by the accumulation of a small number of genetic alterations. However, these few driver alterations reside in a cancer genome alongside tens of thousands of additional mutations termed passengers. Passengers are widely believed to have no role in cancer, yet many passeng...

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Bibliographic Details
Main Authors: Korolev, Kirill Sergeevich, Sunyaev, Shamil R., McFarland, Christopher D., Kryukov, Gregory V., Mirny, Leonid A
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Format: Article
Language:en_US
Published: National Academy of Sciences (U.S.) 2013
Online Access:http://hdl.handle.net/1721.1/80381
https://orcid.org/0000-0002-0785-5410