Generation of a stable, aminotyrosyl radical-induced α2β2 complex of Escherichia coli class Ia ribonucleotide reductase

Generation of a stable, aminotyrosyl radical-induced α2β2 complex of Escherichia coli class Ia ribonucleotide reductase

Ribonucleotide reductase (RNR) catalyzes the conversion of nucleoside diphosphates to deoxynucleoside diphosphates (dNDPs). The Escherichia coli class Ia RNR uses a mechanism of radical propagation by which a cysteine in the active site of the RNR large (α2) subunit is transiently oxidized by a stab...

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Bibliographic Details
Main Authors: Minnihan, Ellen Catherine, Ando, Nozomi, Olshansky, Lisa, Chittuluru, Johnathan, Asturias, Francisco J., Nocera, Daniel G., Stubbe, JoAnne, Brignole, Edward J, Drennan, Catherine L
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: National Academy of Sciences (U.S.) 2013
Online Access:http://hdl.handle.net/1721.1/80387
https://orcid.org/0000-0001-5486-2755
https://orcid.org/0000-0002-0137-3234
https://orcid.org/0000-0001-8076-4489
https://orcid.org/0000-0002-4507-1115

Internet

http://hdl.handle.net/1721.1/80387
https://orcid.org/0000-0001-5486-2755
https://orcid.org/0000-0002-0137-3234
https://orcid.org/0000-0001-8076-4489
https://orcid.org/0000-0002-4507-1115

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