Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease

Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease

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Huntington disease (HD) is a devastating, late-onset, inherited neurodegenerative disorder that manifests with personality changes, movement disorders, and cognitive decline. It is caused by a CAG repeat expansion in exon 1 of the HTT gene that translates to a polyglutamine tract in the huntingtin p...

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Bibliographic Details
Main Authors: Sathasivam, Kirupa, Neueder, Andreas, Landles, Christian, Benjamin, Agnesska C., Bondulich, Marie K., Smith, Donna L., Faull, Richard L. M., Roos, Raymund A. C., Howland, David, Detloff, Peter J., bates, Gillian P., Wasylenko, Theresa Anne, Housman, David E
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: National Academy of Sciences (U.S.) 2013
Online Access:http://hdl.handle.net/1721.1/80388
https://orcid.org/0000-0002-0524-5301
https://orcid.org/0000-0001-5016-0756

Internet

http://hdl.handle.net/1721.1/80388
https://orcid.org/0000-0002-0524-5301
https://orcid.org/0000-0001-5016-0756

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