Polymer-attached zanamivir inhibits synergistically both early and late stages of influenza virus infection

Polymer-attached zanamivir inhibits synergistically both early and late stages of influenza virus infection

Covalently conjugating multiple copies of the drug zanamivir (ZA; the active ingredient in Relenza) via a flexible linker to poly-l-glutamine (PGN) enhances the anti-influenza virus activity by orders of magnitude. In this study, we investigated the mechanisms of this phenomenon. Like ZA itself, the...

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Bibliographic Details
Main Authors: Lee, Chia Min, Weight, Alisha Kessel, Haldar, Jayanta, Wang, Ling, Klibanov, Alexander M., Chen, Jianzhu
Other Authors: Massachusetts Institute of Technology. Computational and Systems Biology Program
Format: Article
Language:en_US
Published: National Academy of Sciences (U.S.) 2013
Online Access:http://hdl.handle.net/1721.1/81198
https://orcid.org/0000-0003-3830-714X
https://orcid.org/0000-0002-5687-6154

Internet

http://hdl.handle.net/1721.1/81198
https://orcid.org/0000-0003-3830-714X
https://orcid.org/0000-0002-5687-6154

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