Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

Control of intracellular reactive oxygen species (ROS) concentrations is critical for cancer cell survival. We show that, in human lung cancer cells, acute increases in intracellular concentrations of ROS caused inhibition of the glycolytic enzyme pyruvate kinase M2 (PKM2) through oxidation of Cys[s...

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Bibliographic Details
Main Authors: Vander Heiden, Matthew G., Anastasiou, Dimitrios, Poulogiannis, George, Asara, John M., Boxer, Matthew B., Jiang, Jian-kang, Shen, Min, Gary, Bellinger, Sasaki, Atsuo T., Locasale, Jason W., Auld, Douglas S., Thomas, Craig J., Cantley, Lewis C., Bellinger, Gary
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: American Association for the Advancement of Science (AAAS) 2013
Online Access:http://hdl.handle.net/1721.1/81210
https://orcid.org/0000-0002-6702-4192

Internet

http://hdl.handle.net/1721.1/81210
https://orcid.org/0000-0002-6702-4192

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