DNA Methylation Impacts Gene Expression and Ensures Hypoxic Survival of Mycobacterium tuberculosis

DNA methylation regulates gene expression in many organisms. In eukaryotes, DNA methylation is associated with gene repression, while it exerts both activating and repressive effects in the Proteobacteria through largely locus-specific mechanisms. Here, we identify a critical DNA methyltransferase i...

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Bibliographic Details
Main Authors: Shell, Scarlet S., Baek, Seung-Hun, Shah, Rupal R., Sassetti, Christopher M., Dedon, Peter C., Fortune, Sarah M., Prestwich, Erin
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Public Library of Science 2013
Online Access:http://hdl.handle.net/1721.1/81235
https://orcid.org/0000-0003-0011-3067