Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486

Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486

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Fragile X syndrome (FXS) is the most common inherited form of autism and intellectual disability and is caused by the silencing of a single gene, fragile X mental retardation 1 (Fmr1). The Fmr1 KO mouse displays phenotypes similar to symptoms in the human condition—including hyperactivity, repetitiv...

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Bibliographic Details
Main Authors: Govindarajan, Arvind, Tonegawa, Susumu, Dolan, Bridget M., Lin, Gregory G., Duron, Sergio G., Campbell, David A., Vollrath, Benedikt, Rao, B. S. Shankaranarayana, Ko, Hui-Yeon, Choi, Se-Young
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: National Academy of Sciences (U.S.) 2013
Online Access:http://hdl.handle.net/1721.1/81290
https://orcid.org/0000-0003-2839-8228
https://orcid.org/0000-0003-3984-6057

Internet

http://hdl.handle.net/1721.1/81290
https://orcid.org/0000-0003-2839-8228
https://orcid.org/0000-0003-3984-6057

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