Behavioral and Structural Responses to Chronic Cocaine Require a Feedforward Loop Involving ΔFosB and Calcium/Calmodulin-Dependent Protein Kinase II in the Nucleus Accumbens Shell

Behavioral and Structural Responses to Chronic Cocaine Require a Feedforward Loop Involving ΔFosB and Calcium/Calmodulin-Dependent Protein Kinase II in the Nucleus Accumbens Shell

The transcription factor ΔFosB and the brain-enriched calcium/calmodulin-dependent protein kinase II (CaMKIIα) are induced in the nucleus accumbens (NAc) by chronic exposure to cocaine or other psychostimulant drugs of abuse, in which the two proteins mediate sensitized drug responses. Although ΔFos...

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Detalhes bibliográficos
Principais autores: Neve, Rachael L., Robison, Alfred J., Vialou, Vincent, Mazei-Robison, Michelle S., Feng, Jian, Kourrich, Said, Collins, Miles, Wee, Sunmee, Koob, George, Turecki, Gustavo, Thomas, Mark, Nestler, Eric J.
Outros Autores: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Formato: Artigo
Idioma:en_US
Publicado em: Society for Neuroscience 2013
Acesso em linha:http://hdl.handle.net/1721.1/81336
https://orcid.org/0000-0002-3854-5968

Internet

http://hdl.handle.net/1721.1/81336
https://orcid.org/0000-0002-3854-5968

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