Behavioral and Structural Responses to Chronic Cocaine Require a Feedforward Loop Involving ΔFosB and Calcium/Calmodulin-Dependent Protein Kinase II in the Nucleus Accumbens Shell

Behavioral and Structural Responses to Chronic Cocaine Require a Feedforward Loop Involving ΔFosB and Calcium/Calmodulin-Dependent Protein Kinase II in the Nucleus Accumbens Shell

The transcription factor ΔFosB and the brain-enriched calcium/calmodulin-dependent protein kinase II (CaMKIIα) are induced in the nucleus accumbens (NAc) by chronic exposure to cocaine or other psychostimulant drugs of abuse, in which the two proteins mediate sensitized drug responses. Although ΔFos...

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Bibliographic Details
Main Authors: Neve, Rachael L., Robison, Alfred J., Vialou, Vincent, Mazei-Robison, Michelle S., Feng, Jian, Kourrich, Said, Collins, Miles, Wee, Sunmee, Koob, George, Turecki, Gustavo, Thomas, Mark, Nestler, Eric J.
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Format: Article
Language:en_US
Published: Society for Neuroscience 2013
Online Access:http://hdl.handle.net/1721.1/81336
https://orcid.org/0000-0002-3854-5968

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http://hdl.handle.net/1721.1/81336
https://orcid.org/0000-0002-3854-5968

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