Palladium-Catalyzed Enantioselective α-Arylation and α-Vinylation of Oxindoles Facilitated by an Axially Chiral P-Stereogenic Ligand

The enantioselective α-arylation and α-vinylation of oxindoles catalyzed by Pd and a biarylmonophosphine ligand with both axial and phosphorus-based chirogenicity is reported. The resultant quaternary carbon stereocenters are formed in high enantiomeric excess, and the conditions tolerate a range of...

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Main Authors: Taylor, Alexander M., Altman, Ryan A., Buchwald, Stephen Leffler
其他作者: Massachusetts Institute of Technology. Department of Chemistry
格式: 文件
语言:en_US
出版: American Chemical Society (ACS) 2013
在线阅读:http://hdl.handle.net/1721.1/81936
https://orcid.org/0000-0003-3875-4775