Palladium-Catalyzed N-Arylation of 2-Aminothiazoles

A method for the Pd-catalyzed coupling of 2-aminothiazole derivatives with aryl bromides and triflates is described. Significantly, for this class of nucleophiles, the coupling exhibits a broad substrate scope and proceeds with a reasonable catalyst loading. Furthermore, an interesting effect of ace...

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Bibliographic Details
Main Authors: McGowan, Meredeth A., Henderson, Jaclyn L., Buchwald, Stephen Leffler
Other Authors: Massachusetts Institute of Technology. Department of Chemistry
Format: Article
Language:en_US
Published: American Chemical Society (ACS) 2013
Online Access:http://hdl.handle.net/1721.1/81945
https://orcid.org/0000-0003-3875-4775