Mechanistic studies of an unprecedented enzyme-catalysed 1,2-phosphono-migration reaction

Mechanistic studies of an unprecedented enzyme-catalysed 1,2-phosphono-migration reaction

(S)-2-hydroxypropylphosphonate ((S)-2-HPP) epoxidase (HppE) is a mononuclear non-haem-iron-dependent enzyme1, 2, 3 responsible for the final step in the biosynthesis of the clinically useful antibiotic fosfomycin4. Enzymes of this class typically catalyse oxygenation reactions that proceed via the f...

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Bibliographic Details
Main Authors: Chang, Wei-chen, Dey, Mishtu, Liu, Pinghua, Mansoorabadi, Steven O., Moon, Sung-Ju, Zhao, Zongbao K., Liu, Hung-wen, Drennan, Catherine L
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Nature Publishing Group 2013
Online Access:http://hdl.handle.net/1721.1/82019
https://orcid.org/0000-0001-5486-2755

Internet

http://hdl.handle.net/1721.1/82019
https://orcid.org/0000-0001-5486-2755

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