An Unusual Role for a Mobile Flavin in StaC-like Indolocarbazole Biosynthetic Enzymes
The indolocarbazole biosynthetic enzymes StaC, InkE, RebC, and AtmC mediate the degree of oxidation of chromopyrrolic acid on route to the natural products staurosporine, K252a, rebeccamycin, and AT2433-A1, respectively. Here, we show that StaC and InkE, which mediate a net 4-electron oxidation, bin...
| Main Authors: | , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Springer Science + Business Media B.V.
2013
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| Online Access: | http://hdl.handle.net/1721.1/82020 https://orcid.org/0000-0001-5486-2755 |