Removal of N-Alkyl Modifications from N[superscript 2]-Alkylguanine and N[superscript 4]-Alkylcytosine in DNA by the Adaptive Response Protein AlkB

Removal of N-Alkyl Modifications from N[superscript 2]-Alkylguanine and N[superscript 4]-Alkylcytosine in DNA by the Adaptive Response Protein AlkB

The AlkB enzyme is an Fe(II)- and α-ketoglutarate-dependent dioxygenase that repairs DNA alkyl lesions by a direct reversal of damage mechanism as part of the adaptive response in E. coli. The reported substrate scope of AlkB includes simple DNA alkyl adducts, such as 1-methyladenine, 3-methylcytosi...

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Bibliographic Details
Main Authors: Li, Deyu, Fedeles, Bogdan I., Shrivastav, Nidhi, Delaney, James C., Yang, Xuedong, Wong, Cintyu, Drennan, Catherine L., Essigmann, John M.
Other Authors: Massachusetts Institute of Technology. Center for Environmental Health Sciences
Format: Article
Language:en_US
Published: American Chemical Society 2013
Online Access:http://hdl.handle.net/1721.1/82033
https://orcid.org/0000-0001-5486-2755
https://orcid.org/0000-0001-6159-0778
https://orcid.org/0000-0002-2196-5691

Internet

http://hdl.handle.net/1721.1/82033
https://orcid.org/0000-0001-5486-2755
https://orcid.org/0000-0001-6159-0778
https://orcid.org/0000-0002-2196-5691

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