Dynamic Nuclear Polarization with a Water-Soluble Rigid Biradical
A new biradical polarizing agent, bTbtk-py, for dynamic nuclear polarization (DNP) experiments in aqueous media is reported. The synthesis is discussed in light of the requirements of the optimum, theoretical, biradical system. To date, the DNP NMR signal enhancement resulting from bTbtk-py is the l...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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American Chemical Society (ACS)
2013
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| Online Access: | http://hdl.handle.net/1721.1/82074 https://orcid.org/0000-0003-1589-832X |
| _version_ | 1826199927372382208 |
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| author | Kiesewetter, Matthew K. Smith, Albert A. Corzilius, Bjorn Griffin, Robert Guy Swager, Timothy M |
| author2 | Massachusetts Institute of Technology. Department of Chemistry |
| author_facet | Massachusetts Institute of Technology. Department of Chemistry Kiesewetter, Matthew K. Smith, Albert A. Corzilius, Bjorn Griffin, Robert Guy Swager, Timothy M |
| author_sort | Kiesewetter, Matthew K. |
| collection | MIT |
| description | A new biradical polarizing agent, bTbtk-py, for dynamic nuclear polarization (DNP) experiments in aqueous media is reported. The synthesis is discussed in light of the requirements of the optimum, theoretical, biradical system. To date, the DNP NMR signal enhancement resulting from bTbtk-py is the largest of any biradical in the ideal glycerol/water solvent matrix, ε = 230. EPR and X-ray crystallography are used to characterize the molecule and suggest approaches for further optimizing the biradical distance and relative orientation. |
| first_indexed | 2024-09-23T11:28:01Z |
| format | Article |
| id | mit-1721.1/82074 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T11:28:01Z |
| publishDate | 2013 |
| publisher | American Chemical Society (ACS) |
| record_format | dspace |
| spelling | mit-1721.1/820742022-09-27T19:43:04Z Dynamic Nuclear Polarization with a Water-Soluble Rigid Biradical Kiesewetter, Matthew K. Smith, Albert A. Corzilius, Bjorn Griffin, Robert Guy Swager, Timothy M Massachusetts Institute of Technology. Department of Chemistry Francis Bitter Magnet Laboratory (Massachusetts Institute of Technology) Kiesewetter, Matthew K. Corzilius, Bjorn Smith, Albert A. Griffin, Robert Guy Swager, Timothy Manning A new biradical polarizing agent, bTbtk-py, for dynamic nuclear polarization (DNP) experiments in aqueous media is reported. The synthesis is discussed in light of the requirements of the optimum, theoretical, biradical system. To date, the DNP NMR signal enhancement resulting from bTbtk-py is the largest of any biradical in the ideal glycerol/water solvent matrix, ε = 230. EPR and X-ray crystallography are used to characterize the molecule and suggest approaches for further optimizing the biradical distance and relative orientation. National Institutes of Health (U.S.) (GM095843) National Institutes of Health (U.S.) (EB002804) National Institutes of Health (U.S.) (EB002026) National Institute for Biomedical Imaging and Bioengineering (U.S.) (NRSA Fellowship F32EB012937) 2013-11-12T13:26:05Z 2013-11-12T13:26:05Z 2012-02 2011-12 Article http://purl.org/eprint/type/JournalArticle 0002-7863 1520-5126 http://hdl.handle.net/1721.1/82074 Kiesewetter, Matthew K., Bjorn Corzilius, Albert A. Smith, Robert G. Griffin, and Timothy M. Swager. “Dynamic Nuclear Polarization with a Water-Soluble Rigid Biradical.” Journal of the American Chemical Society 134, no. 10 (March 14, 2012): 4537-4540. https://orcid.org/0000-0003-1589-832X en_US http://dx.doi.org/10.1021/ja212054e Journal of the American Chemical Society Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf American Chemical Society (ACS) PMC |
| spellingShingle | Kiesewetter, Matthew K. Smith, Albert A. Corzilius, Bjorn Griffin, Robert Guy Swager, Timothy M Dynamic Nuclear Polarization with a Water-Soluble Rigid Biradical |
| title | Dynamic Nuclear Polarization with a Water-Soluble Rigid Biradical |
| title_full | Dynamic Nuclear Polarization with a Water-Soluble Rigid Biradical |
| title_fullStr | Dynamic Nuclear Polarization with a Water-Soluble Rigid Biradical |
| title_full_unstemmed | Dynamic Nuclear Polarization with a Water-Soluble Rigid Biradical |
| title_short | Dynamic Nuclear Polarization with a Water-Soluble Rigid Biradical |
| title_sort | dynamic nuclear polarization with a water soluble rigid biradical |
| url | http://hdl.handle.net/1721.1/82074 https://orcid.org/0000-0003-1589-832X |
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