Nanowire-Mediated Delivery Enables Functional Interrogation of Primary Immune Cells: Application to the Analysis of Chronic Lymphocytic Leukemia

A circuit level understanding of immune cells and hematological cancers has been severely impeded by a lack of techniques that enable intracellular perturbation without significantly altering cell viability and function. Here, we demonstrate that vertical silicon nanowires (NWs) enable gene-specific...

Full beskrivning

Bibliografiska uppgifter
Huvudupphovsmän: Shalek, Alex K., Gaublomme, Jellert T., Wang, Lili, Yosef, Nir, Chevrier, Nicolas, Andersen, Mette S., Robinson, Jacob T., Pochet, Nathalie, Neuberg, Donna S., Gertner, Rona S., Amit, Ido, Brown, Jennifer R., Hacohen, Nir, Regev, Aviv, Wu, Catherine J., Park, Hongkun
Övriga upphovsmän: Massachusetts Institute of Technology. Department of Biology
Materialtyp: Artikel
Språk:en_US
Publicerad: American Chemical Society (ACS) 2013
Länkar:http://hdl.handle.net/1721.1/82108
https://orcid.org/0000-0001-8567-2049