Water Overcomes Methyl Group Directing Effects in Epoxide-Opening Cascades

Water is an effective promoter of the endo-selective opening of trisubstituted epoxides, enabling related cascades leading to a variety of substituted ladder polyether structures. When used in conjunction with a tetrahydropyran-templated nucleophile, water can overcome the powerful electronic direct...

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Bibliographic Details
Main Authors: Morten, Christopher J., Jamison, Timothy F.
Other Authors: Massachusetts Institute of Technology. Department of Chemistry
Format: Article
Language:en_US
Published: American Chemical Society (ACS) 2013
Online Access:http://hdl.handle.net/1721.1/82116
https://orcid.org/0000-0002-8601-7799