Polyvalent Oligonucleotide Gold Nanoparticle Conjugates as Delivery Vehicles for Platinum(IV) Warheads

Polyvalent Oligonucleotide Gold Nanoparticle Conjugates as Delivery Vehicles for Platinum(IV) Warheads

Amine-functionalized polyvalent oligonucleotide gold nanoparticles (DNA-Au NPs) were derivatized with a cisplatin prodrug, and the resulting DNA-Au NP conjugates were used to internalize multiple platinum centers. A platinum(IV) complex, c,c,t-[Pt(NH[subscript 3])[subscript 2]Cl[subscript 2](OH)(O[s...

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Bibliographic Details
Main Authors: Dhar, Shanta, Daniel, Weston L., Giljohann, David A., Mirkin, Chad A., Lippard, Stephen J.
Other Authors: Massachusetts Institute of Technology. Department of Chemistry
Format: Article
Language:en_US
Published: American Chemical Society (ACS) 2013
Online Access:http://hdl.handle.net/1721.1/82149
https://orcid.org/0000-0002-2693-4982

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http://hdl.handle.net/1721.1/82149
https://orcid.org/0000-0002-2693-4982

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