Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels

Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels

Cancer and stromal cells actively exert physical forces (solid stress) to compress tumour blood vessels, thus reducing vascular perfusion. Tumour interstitial matrix also contributes to solid stress, with hyaluronan implicated as the primary matrix molecule responsible for vessel compression because...

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Bibliographic Details
Main Authors: Chauhan, Vikash P., Liu, Hao, Lacorre, Delphine A., Jain, Saloni R., Kozin, Sergey V., Stylianopoulos, Triantafyllos, Mousa, Ahmed S., Han, Xiaoxing, Adstamongkonkul, Pichet, Huang, Peigen, Bawendi, Moungi G., Boucher, Yves, Jain, Rakesh K., Martin, John Daniel, Popovic, Zoran
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering
Format: Article
Language:en_US
Published: Nature Publishing Group 2013
Online Access:http://hdl.handle.net/1721.1/82573
https://orcid.org/0000-0003-2220-4365

Internet

http://hdl.handle.net/1721.1/82573
https://orcid.org/0000-0003-2220-4365

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