Systematic dissection of regulatory motifs in 2000 predicted human enhancers using a massively parallel reporter assay

Systematic dissection of regulatory motifs in 2000 predicted human enhancers using a massively parallel reporter assay

Genome-wide chromatin annotations have permitted the mapping of putative regulatory elements across multiple human cell types. However, their experimental dissection by directed regulatory motif disruption has remained unfeasible at the genome scale. Here, we use a massively parallel reporter assay...

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Dades bibliogràfiques
Autors principals: Kheradpour, Pouya, Kellis, Manolis, Ernst, Jason, Melnikov, Alexandre, Rogov, Peter, Wang, Li, Zhang, Xiaolan, Alston, Jessica, Mikkelsen, Tarjei Sigurd
Altres autors: Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory
Format: Article
Idioma:en_US
Publicat: Cold Spring Harbor Laboratory Press 2013
Accés en línia:http://hdl.handle.net/1721.1/82916

Internet

http://hdl.handle.net/1721.1/82916

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