Structure-based whole-genome realignment reveals many novel noncoding RNAs

Recent genome-wide computational screens that search for conservation of RNA secondary structure in whole-genome alignments (WGAs) have predicted thousands of structural noncoding RNAs (ncRNAs). The sensitivity of such approaches, however, is limited, due to their reliance on sequence-based whole-ge...

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Bibliographic Details
Main Authors: Will, Sebastian, Berger, Bonnie, Yu, Michael
Other Authors: Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory
Format: Article
Language:en_US
Published: Cold Spring Harbor Laboratory Press 2013
Online Access:http://hdl.handle.net/1721.1/82919
https://orcid.org/0000-0002-2724-7228