Nucleotide Binding and Conformational Switching in the Hexameric Ring of a AAA+ Machine
ClpX, a AAA+ ring homohexamer, uses the energy of ATP binding and hydrolysis to power conformational changes that unfold and translocate target proteins into the ClpP peptidase for degradation. In multiple crystal structures, some ClpX subunits adopt nucleotide-loadable conformations, others adopt u...
| Main Authors: | , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Elsevier B.V.
2013
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| Online Access: | http://hdl.handle.net/1721.1/82944 https://orcid.org/0000-0002-9309-8662 https://orcid.org/0000-0002-1719-5399 |