Small-Molecule Control of Protein Degradation Using Split Adaptors

Targeted intracellular degradation provides a method to study the biological function of proteins and has numerous applications in biotechnology. One promising approach uses adaptor proteins to target substrates with genetically encoded degradation tags for proteolysis. Here, we describe an engineer...

Full description

Bibliographic Details
Main Authors: Davis, Joseph Harry, Baker, Tania, Sauer, Robert T.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: American Chemical Society 2013
Online Access:http://hdl.handle.net/1721.1/82946
https://orcid.org/0000-0002-1719-5399