Redesign of a cross-reactive antibody to dengue virus with broad-spectrum activity and increased in vivo potency

Redesign of a cross-reactive antibody to dengue virus with broad-spectrum activity and increased in vivo potency

Affinity improvement of proteins, including antibodies, by computational chemistry broadly relies on physics-based energy functions coupled with refinement. However, achieving significant enhancement of binding affinity (>10-fold) remains a challenging exercise, particularly for cross-reactive an...

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Bibliographic Details
Main Authors: Raguram, S., Sasisekharan, V., Tharakaraman, Kannan, Robinson, Luke Nathaniel, Hatas, Andrew, Chen, Yiling, Sasisekharan, Ram, Siyue, Liu, Wogan, Gerald N
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: National Academy of Sciences (U.S.) 2013
Online Access:http://hdl.handle.net/1721.1/83370
https://orcid.org/0000-0002-2085-7840
https://orcid.org/0000-0003-0771-9889

Internet

http://hdl.handle.net/1721.1/83370
https://orcid.org/0000-0002-2085-7840
https://orcid.org/0000-0003-0771-9889

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