Differential Remodeling of Actin Cytoskeleton Architecture by Profilin Isoforms Leads to Distinct Effects on Cell Migration and Invasion

Differential Remodeling of Actin Cytoskeleton Architecture by Profilin Isoforms Leads to Distinct Effects on Cell Migration and Invasion

Dynamic actin cytoskeletal reorganization is integral to cell motility. Profilins are well-characterized regulators of actin polymerization; however, functional differences among coexpressed profilin isoforms are not well defined. Here, we demonstrate that profilin-1 and profilin-2 differentially re...

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Bibliographic Details
Main Authors: Mouneimne, Ghassan, Hansen, Scott D., Selfors, Laura M., Petrak, Lara, Hickey, Michele M., Gallegos, Lisa L., Simpson, Kaylene J., Lim, James, Gertler, Frank, Hartwig, John H., Mullins, R. Dyche, Brugge, Joan S.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Elsevier 2014
Online Access:http://hdl.handle.net/1721.1/83487
https://orcid.org/0000-0003-3214-4554

Internet

http://hdl.handle.net/1721.1/83487
https://orcid.org/0000-0003-3214-4554

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