Targeting p35/Cdk5 Signalling via CIP-Peptide Promotes Angiogenesis in Hypoxia

Targeting p35/Cdk5 Signalling via CIP-Peptide Promotes Angiogenesis in Hypoxia

Cyclin-dependent kinase-5 (Cdk5) is over-expressed in both neurons and microvessels in hypoxic regions of stroke tissue and has a significant pathological role following hyper-phosphorylation leading to calpain-induced cell death. Here, we have identified a critical role of Cdk5 in cytoskeleton/foca...

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Bibliographic Details
Main Authors: Bosutti, Alessandra, Qi, Jie, Pennucci, Roberta, Bolton, David, Matou, Sabine, Ali, Kamela, Tsai, Li-Huei, Krupinski, Jerzy, Petcu, Eugene B., Montaner, Joan, Al Baradie, Raid, Caccuri, Francesca, Caruso, Arnaldo, Alessandri, Giulio, Kumar, Shant, Rodriguez, Cristina, Martinez-Gonzalez, Jose, Slevin, Mark
Other Authors: Picower Institute for Learning and Memory
Format: Article
Language:en_US
Published: Public Library of Science 2014
Online Access:http://hdl.handle.net/1721.1/83510
https://orcid.org/0000-0003-1262-0592

Internet

http://hdl.handle.net/1721.1/83510
https://orcid.org/0000-0003-1262-0592

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