Statistical Experimental Design Guided Optimization of a One-Pot Biphasic Multienzyme Total Synthesis of Amorpha-4,11-diene

Statistical Experimental Design Guided Optimization of a One-Pot Biphasic Multienzyme Total Synthesis of Amorpha-4,11-diene

In vitro synthesis of chemicals and pharmaceuticals using enzymes is of considerable interest as these biocatalysts facilitate a wide variety of reactions under mild conditions with excellent regio-, chemo- and stereoselectivities. A significant challenge in a multi-enzymatic reaction is the need to...

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Bibliographic Details
Main Authors: Chen, Xixian, Zhang, Congqiang, Zou, Ruiyang, Zhou, Kang, Stephanopoulos, Gregory, Too, Heng Phon
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering
Format: Article
Language:en_US
Published: Public Library of Science 2014
Online Access:http://hdl.handle.net/1721.1/83517
https://orcid.org/0000-0001-6909-4568

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http://hdl.handle.net/1721.1/83517
https://orcid.org/0000-0001-6909-4568

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