Transcriptional Amplification in Tumor Cells with Elevated c-Myc
Elevated expression of the c-Myc transcription factor occurs frequently in human cancers and is associated with tumor aggression and poor clinical outcome. The effect of high levels of c-Myc on global gene regulation is poorly understood but is widely thought to involve newly activated or repressed...
Main Authors: | Lin, Charles Y., Loven, Jakob, Rahl, Peter B., Paranal, Ronald M., Burge, Christopher B., Bradner, James E., Lee, Tong Ihn, Young, Richard A. |
---|---|
Other Authors: | Massachusetts Institute of Technology. Computational and Systems Biology Program |
Format: | Article |
Language: | en_US |
Published: |
Elsevier B.V.
2014
|
Online Access: | http://hdl.handle.net/1721.1/83614 https://orcid.org/0000-0001-8855-8647 |
Similar Items
-
c-Myc regulates transcriptional pause release
by: Rahl, Peter B., et al.
Published: (2012) -
Registered report: Transcriptional amplification in tumor cells with elevated c-Myc
by: Blum, D, et al.
Published: (2015) -
Registered report: Transcriptional amplification in tumor cells with elevated c-Myc
by: David Blum, et al.
Published: (2015-01-01) -
Replication Study: Transcriptional amplification in tumor cells with elevated c-Myc
by: L Michelle Lewis, et al.
Published: (2018-01-01) -
Dissecting transcriptional amplification by MYC
by: Zuqin Nie, et al.
Published: (2020-07-01)