The Effects of Somatic Hypermutation on Neutralization and Binding in the PGT121 Family of Broadly Neutralizing HIV Antibodies

The Effects of Somatic Hypermutation on Neutralization and Binding in the PGT121 Family of Broadly Neutralizing HIV Antibodies

Broadly neutralizing HIV antibodies (bnAbs) are typically highly somatically mutated, raising doubts as to whether they can be elicited by vaccination. We used 454 sequencing and designed a novel phylogenetic method to model lineage evolution of the bnAbs PGT121–134 and found a positive correlation...

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Bibliographic Details
Main Authors: Sok, Devin, Laserson, Uri, Laserson, Jonathan, Liu, Yi, Vigneault, Francois, Julien, Jean-Philippe, Briney, Bryan, Ramos, Alejandra, Saye, Karen F., Le, Khoa, Mahan, Alison E., Wang, Shenshen, Kardar, Mehran, Yaari, Gur, Walker, Laura M., Simen, Birgitte B., St. John, Elizabeth P., Chan-Hui, Po-Ying, Swiderek, Kristine, Kleinstein, Stephen H., Alter, Galit, Seaman, Michael S., Koller, Daphne, Wilson, Ian A., Burton, Dennis R., Poignard, Pascal, Chakraborty, Arup K, Church, George M
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Format: Article
Language:en_US
Published: Public Library of Science 2014
Online Access:http://hdl.handle.net/1721.1/83865
https://orcid.org/0000-0002-6064-0531
https://orcid.org/0000-0003-1268-9602
https://orcid.org/0000-0002-1112-5912

Internet

http://hdl.handle.net/1721.1/83865
https://orcid.org/0000-0002-6064-0531
https://orcid.org/0000-0003-1268-9602
https://orcid.org/0000-0002-1112-5912

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