Genetic Predisposition Directs Breast Cancer Phenotype by Dictating Progenitor Cell Fate
Women with inherited mutations in the BRCA1 gene have increased risk of developing breast cancer but also exhibit a predisposition for the development of aggressive basal-like breast tumors. We report here that breast epithelial cells derived from patients harboring deleterious mutations in BRCA1 (B...
Main Authors: | Proia, Theresa A., Keller, Patricia J., Klebba, Ina, Jones, Ainsley D., Sedic, Maja, Gilmore, Hannah, Tung, Nadine, Naber, Stephen P., Schnitt, Stuart, Gupta, Piyush, Kuperwasser, Charlotte, Lander, Eric Steven |
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Other Authors: | Massachusetts Institute of Technology. Department of Biology |
Format: | Article |
Language: | en_US |
Published: |
Elsevier
2014
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Online Access: | http://hdl.handle.net/1721.1/84488 https://orcid.org/0000-0002-9703-1780 |
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