Genetic Predisposition Directs Breast Cancer Phenotype by Dictating Progenitor Cell Fate

Women with inherited mutations in the BRCA1 gene have increased risk of developing breast cancer but also exhibit a predisposition for the development of aggressive basal-like breast tumors. We report here that breast epithelial cells derived from patients harboring deleterious mutations in BRCA1 (B...

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Bibliographic Details
Main Authors: Proia, Theresa A., Keller, Patricia J., Klebba, Ina, Jones, Ainsley D., Sedic, Maja, Gilmore, Hannah, Tung, Nadine, Naber, Stephen P., Schnitt, Stuart, Gupta, Piyush, Kuperwasser, Charlotte, Lander, Eric Steven
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Elsevier 2014
Online Access:http://hdl.handle.net/1721.1/84488
https://orcid.org/0000-0002-9703-1780

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